Plasma glutamine is associated with multiple organ failure in critically ill children

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613001298707

Enrollment

150

Registered

2013-11-22

Start date

2007-10-15

Completion date

2008-06-06

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Low plasma glutamine concentration (< 420 micromol/L) is an independent risk factor for mortality in critically ill adult patients. Glutamine metabolism in children is less well characterized. However, the PICU mortality is low and therefore mortality is difficult to use as an endpoint. Here we evaluated if plasma glutamine concentration at admission to the PICU relates to the development of multiple organ failure, using PELOD-score as a surrogate marker of mortality. In this observational study, consecutive critically ill children (n = 149) admitted to the PICU of a tertiary university hospital as well as a reference group of healthy children (n=60) were included. Plasma glutamine concentration and the pediatric logistic organ dysfunction score (PELOD) were determined at admission and at day 5 for patients still in the PICU.

Interventions

In this observational study, consecutive critically ill children (n = 149) admitted to the PICU of a tertiary university hospital as well as a reference group of healthy children (n=60) were included. Plasma glutamine concentration and the pediatric logistic organ dysfunction score (PELOD) were determined at admission and at day 5 for patients still in the PICU.

Eligibility

Sex/Gender

All

Age

0 to 18 Years

Healthy volunteers

Inclusion criteria

An expected PICU-stay > 24 hours, informed consent and sampling within 48 hours after admittance.

Exclusion criteria

Absence of informed consent at 48 hours after admittance, failure of sampling or age > 18 years.

Outcome results