The importance of Microcirculation in Liver resection

The importance of hepatic microcirculation and the pathophysiological role of endothelia-1 in major liver resection

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613001293752

Acronym

MERP-RESECTION

Enrollment

Registered

2013-11-21

Start date

2013-12-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Forty patients undergoing major liver resection will be included in the study. Data regarding preoperative variables, intraoperative and postoperative variables are prospectively collected. A non-invasive device (called Sidestream Dark Field imaging), that allow for clinical observation of the microcirculation will be used. It is hand-held probe with a sterile extension for direct contact with liver parenchyma. Portal vein and hepatic artery flow will be measured intraoperatively. Liver biopsies are performed to assess Immunohystochemical intensity of ET-1 and other markers. The tissue to be acquired in this study will be obtained from surgical specimens taken from consented participants having liver resection.

Interventions

Forty patients undergoing major liver resection will be included in the study. Data regarding preoperative variables, intraoperative and postoperative variables are prospectively collected. A non-invasive device (called Sidestream Dark Field imaging), that allow for clinical observation of the microcirculation will be used before liver resection and 30 minutes after liver resection.. It is hand-held probe with a sterile extension for direct contact with liver parenchyma. Portal vein and hepatic artery flow will be measured intraoperatively before resection and 30 min after liver resection.. Liver biopsies are performed before resection and 30 min after liver resection.. to assess Immunohystochemical intensity of ET-1 and other markers. The tissue to be acquired in this study will be obtained from surgical specimens taken from consented participants having liver resection.

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

patients undergoing major liver resection

Exclusion criteria

Patients undergoing minor resection

Outcome results