None listed
Conditions
Brief summary
Previously it has been found that a tyrosine kinase inhibitor can reverse gray hairs of receivers. Tyrosine is an important precursor of melanin, an agent that directly produces hair color. This study for the first time investigates the effect of oral L-tyrosin (plus other important factors in the metabolism of melanin) in possible reversing of gray hair.
Interventions
Three groups of normal men with gray hair (total=15) will receive daily oral L-tyrosin 500 mg or 3000 mg daily plus other essential elements including 50 mg (in cases on 500 mg L-tyrosin) or 300 mg (in cases on 3000 mg L-tyrosin) 5-hydroxytriptophan (5-HTP) and 500 mg cysteine (Dr Daniel capsule for gray hair) in the intervention groups; or oral placebo (glucose) in the control group for 6 consecutive months.
Diet will be similar during the study period in all three groups.
Adherence interventio
Three groups of normal men with gray hair (total=15) will receive daily oral L-tyrosin 500 mg or 3000 mg daily plus other essential elements including 50 mg (in cases on 500 mg L-tyrosin) or 300 mg (in cases on 3000 mg L-tyrosin) 5-hydroxytriptophan (5-HTP) and 500 mg cysteine (Dr Daniel capsule for gray hair) in the intervention groups; or oral placebo (glucose) in the control group for 6 consecutive months. Diet will be similar during the study period in all three groups. Adherence interventions will include monthly instruction in forms of oral and written material. Adherence to taking medication will be monitored by drug capsule return monthly.
Sponsors
Daniel F Fouladi
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
Male
Age
30 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Normal men with gray hair.
Exclusion criteria
Secondary gray hair, malnutrition, taking other medications/supplements.
Outcome results
None listed