High Flow Humidified Nasal Cannula versus Standardised Oxygen Therapy

A comparative study of high flow humidified nasal cannula versus standardised oxygen therapy for adult patients who present to the emergency department in respiratory distress. Success will be determined by a decrease in respiratory rate by 20% by the end of the second hour from the time therapy was commenced.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613001264774

Enrollment

100

Registered

2013-11-18

Start date

2013-11-25

Completion date

2015-02-14

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to define which patients will benefit most from the High Flow Humidified Nasal Cannula as apposed to standard oxygen therapy in the acute Emergency department setting. Outcomes which we will be measuring include improved vital signs, length of stay in the Emergency Department, need for escalation to non invasive and invasive ventialtion and patient comfort.

Interventions

Humidified high flow nasal cannula is a supplementary oxygen therapy that provides a complete range of flow as well as fraction of inspired oxygen (Fi02) beyond that of standard oxygen therapy. The higher flows up to 60 litres allows the patients inspiratory demand to be met. With the aim to reduce their work of breathing. Additionally being able to prescribe the Fi02 (ranges between 21%-100%) independently to the flow to meet the patients individual needs. Adult patients who present to one of two metropolitan Emergency Departments with dyspnoea and a respiratory rate greater or equal to 25 and oxygen saturations of equal or less than 93% on room air will be randomised to either high flow nasal cannula or standard oxygen therapy. Both therapies will be titrated to the patients individual requirements while in the Emergency Department (ED). We will be assessing the outcomes of the treatment for the duration of the patient stay in the ED

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Investigator)

Eligibility

Sex/Gender

All

Age

16 Years to 110 Years

Healthy volunteers

Inclusion criteria

Patients who are 16years and over who present with dyspnoea and a respiratory rate great or equal to 25 and oxygen saturations of less than or equal to 93% on room air to either Royal Prince Alfred ED or Canterbury Hospital ED

Exclusion criteria

1. Patients presenting to the ED who require immediate BiPAP or intubation/ventilation 2. Any patient under the age 16 3. Patients who have received a trauma call; including facial trauma, chest trauma 4. Patients with suspected spontaneous pneumothorax 5. Patients who are unable to provide informed consent (cognitive impairment, intoxication from drugs and/or alcohol, intellectual disability, mental illness)

Outcome results