A randomised controlled trial evaluating if antibiotics given before complex skin surgery on the ear,nose or below knee will prevent infection

Do antibiotics given before complex skin surgery on the ear,nose or below knee prevent infection: a prospective randomized placebo-controlled double blinded trial.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613001253796

Enrollment

252

Registered

2013-11-14

Start date

2013-12-04

Completion date

2016-02-28

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study is to discover if antibiotics given prior to complex surgery on the nose, ear or below knee prevents infection.

Interventions

2g (in 4 capsules) cephalexin given orally 30-60 minutes prior to flap or graft surgery on the ear, nose or below knee

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

flap or graft surgery to nose, ear or below knee

Exclusion criteria

Infection at time of surgery; allergy to penicillin or cephalosporins; antibiotic use within 48hrs of surgery; wider excision if previously recruited to trial; allergy to sutures or dressings used in trial

Outcome results