Protein-bound uraemic toxins in Peritoneal Dialysis Patients

Removal of selected low molecular weight highly protein-bound uraemic toxins in patients on peritoneal dialysis

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613001250729

Enrollment

Registered

2013-11-13

Start date

2013-12-30

Completion date

2014-02-28

Last updated

2021-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study looks at the protein binding of low molecular weight highly protein-bound toxins in Peritoneal Effuent of patients on Peritoneal Dialysis

Interventions

Measurement of protein binding of small molecular weight toxins in peritoneal dialysis effluent assessed on 2 occasions 1 month apart Measurement is undertaken with an HPLC assay for simultaneous determination of 4 uraemic solutes:P Cresol,P Cresol Sulphate,Indoxyl Sulphate,3-indole-acteic acid based on methods described by Calaf et al:J Chromatogr B Analyt Technol Biomed Life Sci. 879(23):2281-2286.2011

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

Patients on Peritoneal Dialysis

Exclusion criteria

Peritonitis within 1 month Excessive co-morbidity

Outcome results