Effect of prandial status on capillary - venous glucose gradient in type 1 diabetes

Effect of prandial status on [capillary-venous] glucose difference, in participants with well controlled type 1 diabetes

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613001162707

Enrollment

Registered

2013-10-21

Start date

2013-11-18

Completion date

2014-03-15

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In healthy volunteers, tissue uptake of glucose after a meal results in a glucose gradient between the capillary blood at the finger and venous blood at the level of the antecubital fossa. We hypothesise that a similar [capillary-glucose] gradient exists in type 1 diabetes patients. If it does, this has implications for calibration of continuous glucose monitors. It also has implications when considering capillary and venous samples to be bio-equivalent when defining hypoglycaemic events, for example during pharmaceutical trials in participants with type 1 diabetes.

Interventions

Capillary and venous glucose responses will be measured one hour and two hours after a buffet breakfast, the content of which is selected by participants. Total period of observation is two hours.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Type 1 diabetes, HbA1c <65mol/mol, on CSII or MDI insulin, ability to estimate insulin:carbohydrate ratio

Exclusion criteria

Pregnancy

Outcome results