Metal ion levels post primary unilateral total knee arthroplasty

Do the patients with well functioning total knee replacement have normal blood metal ion levels compare to normal population?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613001149752

Enrollment

Registered

2013-10-15

Start date

2012-04-01

Completion date

2012-12-01

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

BACKGROUND: Metal ion release from metal implants through the processes of mechanical wear and corrosion has been one of the main concerns post total joint arthroplasty. However, there have been very few studies to show metal ion exposure post total knee implants. AIM: The aim of this study was to investigate whether blood metal ion levels are raised in patients with well-functioning unilateral primary total knee arthroplasty one year after surgery. METHODS: Whole blood Chromium and serum Cobalt levels were measured in 22 patients following primary total knee arthroplasty. Eleven patients had the cemented triathlon knee system and 11 patients had uncemented ACS knee system with multilayer coatings. RESULTS: Whole bloods Chromium and serum Cobalt levels were within the normal range. CONCLUSION: On the basis of our results, there does not appear to be any significant rise in blood metal ion levels following well-functioning total knee arthroplasty in one-year post surgery.

Interventions

Whole blood Chromium and serum Cobalt levels were measured in 22 patients , one year after primary total knee arthroplasty,two types of prosthesis were used,11 patients had triathlon knee system and 11 patients had ACS knee system.

Eligibility

Sex/Gender

All

Age

58 Years to 84 Years

Healthy volunteers

Yes

Inclusion criteria

1. Minimum one year post primary unilateral total knee arthroplasty with no other metal implants 2. Well-functioning knee based on clinical findings; including pain, range of movement and stability of the knee. Active patients with no pain, no limited rang of movement, mobility without any walking aids and stable knee in clinical assessment were included in this study. 3. No clinical signs or symptoms of infection 4. No radiographic signs of loosening

Exclusion criteria

Patients with prosthesis or metal work elsewhere in the body, systemic disease affecting metal metabolism, renal impairment (including chronic renal failure with eGFR < 30) or chronic/occupational exposure to metal ions were excluded from this study.

Outcome results