None listed
Conditions
Brief summary
To see if a genetic test helps guide antidepressant dosing for better outcomes in depression treatment.
Interventions
Pharmacogenetic treatment algorithm and report to guide antidepressant dosing.
[1]
a) Patients give a buccal brush sample for DNA analysis of polymorphisms implicated in pharmacokinetic pathways
b) the algorithm provides guidance on the dosing of the antidepressant, type of antidepressant is at clinical discretion
c) any commonly used oral antidepressant currently PBS approved for treatment of major depression can be administered.
d) treatment phase of the study is 12 weeks with daily medication
Pharmacogenetic treatment algorithm and report to guide antidepressant dosing. [1] a) Patients give a buccal brush sample for DNA analysis of polymorphisms implicated in pharmacokinetic pathways b) the algorithm provides guidance on the dosing of the antidepressant, type of antidepressant is at clinical discretion c) any commonly used oral antidepressant currently PBS approved for treatment of major depression can be administered. d) treatment phase of the study is 12 weeks with daily medication dosing [2] Compliance to medication is based on patient report to their prescriber and pharmacy collection of medication.
Sponsors
Dr Ajeet Singh
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Principal Diagnosis Major Depression Requires antidepressant treatment clinically
Exclusion criteria
Pregnant or Breastfeeding Conditions where antidepressants contra-indicated Unable to give informed valid consent
Outcome results
None listed