Interactions of osteocalcin, adiponectin, tumor necrosis factor alpha and insulin resistance in polycystic ovary syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613001132730

Enrollment

Registered

2013-10-11

Start date

2010-11-01

Completion date

2012-11-01

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Objective: Insulin resistance (IR) seems to be main pathogenic factor in polycystic ovary syndrome (PCOS). Osteocalcin, adiponectin and tumor necrosis factor alpha (TNF-a) are also implicated from IR. The aim of this study was to evaluate the correlations of osteocalcin with IR, adiponectin, and TNF-a in PCOS. Study Design: A total of 74 women were divided into two groups. Group 1 was constituted from 55 PCOS patients and group 2 was constituted from 19 healthy women. Adiponectin, TNF-a, osteocalcine, hormonal levels, body mass index, IR in the fasting state were assessed and correlations of these parameters with each other were evaluated in 74 women.

Interventions

Blood levels of hormones is assesed during administration to our clinic. These are thyroid stimulating hormone, cortisol, dehydroepiandrosterone sulfate, prolactin, luteinizing hormone, follicle-stimulating hormone, estradiol, 17-hydroxyprogesterone, Androstenedione, Adiponectin, TNF alpha, osteocalcine, free testosterone, total testosterone, insulin and sex hormone binding globulin levels. We assessed at baseline and then again 6 months later.

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Healthy volunteers

Inclusion criteria

A total of 74 women including 55 PCOS patients (group-1) and 19 healthy women (group-2) were studied.

Exclusion criteria

Previous medication with hormone ( 6 months prior to study), liver disease, kidney disease, cardiac and vascular disorders

Outcome results