Post-Prandial Effects of Dairy Products in Middle-Aged Men

The effect of two novel dairy products versus two standard dairy products on muscle protein synthesis in middle-aged men

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613001100785

Enrollment

Registered

2013-10-02

Start date

2013-09-23

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Aging is associated with a progressive loss of muscle mass and muscle function. Nutritional interventions which can help maintain muscle health during middle-age may improve quality of life in later years. The objective of the study is to evaluate the post-prandial effects of dairy products on muscle protein synthesis and muscle metabolism biomarkers. The study is a double-blind, randomized, controlled, parallel design. 48 healthy middle-aged males (45-60 yrs), BMI 18-30kg/m2 will be recruited, and muscle composition and muscle function tests conducted. After an overnight fast, subjects will consume one of six dairy beverages containing an equivalent content of 20g protein as standard milk protein concentrate (MPC1/20), 20g protein as propriety milk protein concentrate (MPC2/20), 20g protein as standard whey protein concentrate (WPC1/20), 20g protein as propriety whey protein concentrate (WPC2/20), 14g protein as propriety milk protein concentrate (MPC2/14) or 8g protein as propriety milk protein concentrate (MPC2/8). Muscle protein synthesis will be determined based on a primed constant infusion of L-[ring-(13)C(6)]phenylalanine and L-[ring-(2)H(2)]tyrosine. The primary end-points are muscle protein synthesis rate, plasma and muscle metabolism biomarkers.

Interventions

Participants will consume one of the six beverages on a single occasion only. Arm 1 – 20 g standard milk protein concentrate (MPC1/20) Arm 2 - 20 g novel milk protein concentrate (MPC2/20) Arm 3 - 20 g standard whey protein concentrate (WPC1/20) Arm 4 - 20 g novel whey protein concentrate (WPC2/20) Arm 5 – 14 g standard milk protein concentrate (MPC2/14) Arm 6 – 8 g standard milk protein concentrate (MPC2/8)

Study design

Allocation

Randomised controlled trial

Primary purpose

Prevention

Eligibility

Sex/Gender

Male

Age

45 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy Male 45-60 yrs BMI (18-30kg/m2) Sedentary to moderately active

Exclusion criteria

Diabetes or cardiovascular disease risk or current pharmaceutical therapy. Other medical conditions impacting on digestion, including diseases of the gastrointestinal tract, allergy to dairy protein and history (or medical management) of mental illness.

Outcome results