Using oral broad-spectrum antibiotics as an adjuvant therapy in conservative management of lumbar disc hernia; a clinical trial

The effect of ciprofloxacin/co-amoxiclav administration during conservative management of patients with herniated lumbar disc on pain severity and patient's satisfaction

Status

Not yet recruiting

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613001074785

Enrollment

Registered

2013-09-25

Start date

2013-09-30

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

According to results of some recent studies, infection may cause Modic changes. This study aims to investigate whether antibiotic therapy along with conventional management of non-surgical lumbar disc herniation may cause better and/or rapid amelioration of symptoms.

Interventions

at least 90 patients with lumbar disc hernia who are candidates of conservative (nonsurgical) treatment will be randomized in three 30-patient, age- and sex-matched groups. Management will be similar in all three groups. One group will receive oral ciprofloxacin, 500mg twice daily for 2 weeks. Another group will receive oral co-amoxical 250 mg three time daily for 2 weeks. In the third group no antibiotic will be administered.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Healthy volunteers

Inclusion criteria

Patients with lumbar disc hernia who are candidates for conservative (nonsurgical) treatment with symptoms present for >6 months

Exclusion criteria

Candidates of surgical treatment, those with active infection, and patients with previous spinal surgery

Outcome results