Preterm Infant Functional and Clinical Outcomes (PIFCO): Understanding Complex Factors That Influence Long Term Outcomes After Preterm Birth

Observational Study of Physiological and Etiological Markers of Long Term Cardiorespiratory and Developmental Outcomes After Preterm Birth Prior to 32 Weeks Gestation

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613001062718

Acronym

PIFCO Study

Enrollment

500

Registered

2013-09-24

Start date

2013-09-24

Completion date

2017-09-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Breathing problems persisting into infancy and later life is an important complication of premature birth with lifelong consequences. Breathing problems often occur together with lung disease, but prematurity can also affect heart and blood vessel development, and weakness of the main breathing muscle (the diaphragm). We will find out how much the heart, lung and muscles each contribute to breathing problems, as well as identify factors such as infection, nutrition and treatments that influence these and other long-term outcomes of very preterm birth. This knowledge will help us to better predict, diagnose, treat and prevent adverse outcomes after preterm birth.

Interventions

Observational study of very preterm infants with intermittent physiological evaluation of: - immunological function (birth, 1 d, 7 d, 36 w PMA, 1 yr corrected age) - cardiorespiratory and diaphragm function (primary measurement at 36 w PMA and 1 yr corrected age, with other intermittent measurements as able to be collected) - neurodevelopmental outcome (1 yr) Observations will be correlated with data pertaining to antenatal and postnatal exposures including demographic variables, gestation, ven

Eligibility

Sex/Gender

All

Age

0 to 14 Weeks

Healthy volunteers

Inclusion criteria

Inpatient at King Edward Memorial Hospital Born at < 32 w gestation (postmenstrual age) Term comparison group - healthy uncomplicated deliveries between 37 and 42 w postmenstrual age

Exclusion criteria

Informed consent unable to be obtained Major congenital abnormalities likely to impact cardiorespiratory function

Outcome results