Local Endometrial Trauma (LET) in Patients with Recurrent Implantation Failure

A comparison of Local Endometrial Trauma (LET) versus no trauma on failed implantation rates in IVF patients with recurrent implantation failure.

Status

Withdrawn

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613001046796

Enrollment

148

Registered

2013-09-19

Start date

2013-12-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The objective of this study is to determine wether local endometrium trauma (LET), applied once during the mid-luteal phase of the cycle preceding in vitro fertilization (IVF) treatment, can improve the chance of pregnancy for women with recurrent implantation failure. The primary aim of this study will be the prescence of fetal heart activity seen on transvaginal ultrasound approximately four weeks after embryo trasnfer. The secondary outcome will be the effect of the LET procedure on positive pregnancy test two weeks after embryo transfer, ongoing pregnancy, pregnancy outcome and complications up to delivery. Endometrail tissue collected during the LET will be analysed for putative markers of successful implantation.

Interventions

Local Endometrial Trauma (LET), a randomised timed Pipelle endometrial biopsy. This would be done in the mid-luteal phase in the month immediately preceding the IVF treatment.

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Eligibility

Sex/Gender

All

Age

21 Years to 39 Years

Healthy volunteers

Inclusion criteria

Patients about to undergo a cycle of IVF/ICSI treatment involving fresh embryo transfer, who has a history of recurrent implantation failure in IVF/ICSI treatment.

Exclusion criteria

Patient under 21 or over 39 years of age Known uterine abnormality Medical contradiction to superovulation, oocyte collection or embryo transfer Unable to give informed consent

Outcome results