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Carotid Artery Calcification on Orthopantomograms.

In patients having panoramic dental radiographs, can the presence of carotid artery calcification predict clinically significant carotid stenosis?

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12613001038785
Acronym
The CACO Study
Enrollment
239
Registered
2013-09-18
Start date
2012-03-19
Completion date
2014-03-21
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

When dental x-rays are performed, there are many structures visible on the x-ray besides the teeth and jaws. One important structure that is sometimes seen is the carotid artery, which supplies blood to the brain. If this artery becomes calcified or “hardened”, it can been seen on a dental orthopantomogram (OPG). Hardening of the arteries can eventually cause these arteries to become blocked, which can lead to a stroke. Some people will have warning signs before having a stroke, but many patients are unaware that they were at risk. We are interested to see if the finding of calcified arteries on routine dental x-rays is related to narrowing of these vessels that could potentially lead to stroke. We will select patients attending for x-rays who are aged 18 years and over. Half of the participants will have calcified carotid arteries on their OPG, and half will not have visible carotid artery calcification, to provide a comparison group. We will ask study participants to attend The Queen Elizabeth Hospital on a single occasion to undergo a carotid artery ultrasound study. The data will then be analysed to ascertain whether carotid artery calcification can predict arterial narrowing, which can help predict stroke risk.

Interventions

When dental x-rays are performed, there are many structures visible on the x-ray besides the teeth and jaws. One important structure that is sometimes seen is the carotid artery, which supplies blood to the brain. If this artery becomes calcified or “hardened”, it can been seen on a dental orthopantomogram (OPG). Hardening of the arteries can eventually cause these arteries to become blocked, which can lead to a stroke. Some people will have warning signs before having a stroke, but many patien

When dental x-rays are performed, there are many structures visible on the x-ray besides the teeth and jaws. One important structure that is sometimes seen is the carotid artery, which supplies blood to the brain. If this artery becomes calcified or “hardened”, it can been seen on a dental orthopantomogram (OPG). Hardening of the arteries can eventually cause these arteries to become blocked, which can lead to a stroke. Some people will have warning signs before having a stroke, but many patients are unaware that they were at risk. We are interested to see if the finding of calcified arteries on routine dental x-rays is related to narrowing of these vessels that could potentially lead to stroke. We have selected patients attending for dental x-rays. Half of the participants will have calcified carotid arteries on their OPG, and half will not have visible carotid artery calcification, to provide a comparison group. The presence or absence of calcification will be determined by the Dental Radiologist for the SA Dental Service. We will ask all study participants to attend The Queen Elizabeth Hospital on a single occasion to undergo a carotid artery ultrasound study. There is no radiation involved with a carotid ultrasound study. The ultrasound is painless, and takes about 30 minutes to perform. We expect it will take about 18 months to recruit people, and to perform all the ultrasound studies.

Sponsors

Dr Sarah Constantine
Lead SponsorIndividual

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Masking
Blinded (masking used) (Subject, Caregiver)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

OPG that shows the carotid area

Exclusion criteria

previous neck surgery

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 5, 2026