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Improving recognition of heart failure using lung ultrasound

Multicentre randomised controlled trial incorporating bedside lung ultrasound into the diagnosis of congestive cardiac failure in breathless older patients

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12613001023741
Acronym
LUS+2014
Enrollment
485
Registered
2013-09-13
Start date
2013-09-30
Completion date
2016-10-31
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This project aims to improve patient care by putting evidence into practice. Secondary gains include improving ultrasound practices, establishing robust predictive values,and eventually reducing certain unnecessary xrays. This technique, once validated, will be of particular use in regional Australia. Many older persons present to the emergency department complaining of breathlessness. This can be an important forewarning of heart failure, but is present in many conditions. In most cases, several tests are carried out to identify those patients with heart failure. Despite these investigations, heart failure is initially misdiagnosed in up to one quarter of patients. The interpretation of chest xray by treating physicians is notoriously fallible. Many European hospitals use bedside lung ultrasound(LUS) to improve their recognition of heart failure, but as the European practice model is significantly different from the Australian, the practice is not common here. The method is cheap, rapid, safe, readily available and causes trivial interference to current management. Our pilot study has already tested the lung ultrasound method in parallel with conventional investigation, without allowing it to influence management. Now we aim to incorporate it within the testing paradigm, by unblinding the treating doctor. We wish to see if the augmented assessment paradigm has a superior diagnostic accuracy to the conventional assessment paradigm. We will start by teaching a cohort of emergency trainee doctors to perform the test. Older patient who present with breathlessness to the ED will be randomised to either conventional or augmented investigation paradigm, track the emergency doctor's diagnosis after lung scan and again after full workup, and then compare the accuracy of these diagnosed in each group against a reference standard of delayed expert chart audit (which includes all prior and subsequent tests and course of disease). The primary endpoint is the difference in diagnostic accuracy between the LUS augmented investigation and the conventional investigation of breathlessness in the emergency department. Secondary endpoints are the sensitivity and specificity of LUS for differentiation of breathlessness. Exploratory endpoints will be the difference in length of stay in hospital between the groups, and the proportion of cases where chest xray contributed extra informationabove that contributed by the LUS.

Interventions

Breathless patients over 60 years old presenting to an emergency department will receive bedside lung ultrasound as part of the assessment phase of the breathlessness. All participants in the trial will receive the standard emergency work-up for breathless. The intervention group will also receive a bedside lung ultrasound. The scan protocol for bedside lung ultrasound takes approximately 2 minutes to complete and involves taking 4 longitudinal images in both lungs. The scan will be interpre

Breathless patients over 60 years old presenting to an emergency department will receive bedside lung ultrasound as part of the assessment phase of the breathlessness. All participants in the trial will receive the standard emergency work-up for breathless. The intervention group will also receive a bedside lung ultrasound. The scan protocol for bedside lung ultrasound takes approximately 2 minutes to complete and involves taking 4 longitudinal images in both lungs. The scan will be interpreted as demonstrating a 'wet' lung - consistent with pulmonary oedema - or a 'dry' lung which is inconsistent with pulmonary oedema.

Sponsors

Queensland Emergency Medicine Research Fund
Lead SponsorOther Collaborative groups

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Diagnosis
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
60 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Breathless patients presenting to the emergency department who are over 60 years old.

Exclusion criteria

The patient is excluded if they are requiring active airway support, if they were involved in trauma or if there are any contagious lesion in the areas for scanning (eg shingles)

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 21, 2026