The characterisation and correlation of cardiovascular haemodynamics and endothelial function in preeclampsia

An observational study of pregnant women with or without preeclampsia or pre-existing hypertension, examining biomarkers of endothelial and placental function, endothelial function in large and small vessels and echocardiographic parameters during the third trimester and in the post-partum period.

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613001016729

Enrollment

110

Registered

2013-09-12

Start date

2013-11-04

Completion date

2015-03-27

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The incidence of preeclampsia is rising in Australia due to increasing numbers of pregnancies in women at high risk for this condition. Our understanding of the pathophysiology is still unclear and the clinical and pathalogical classifications are inconsistent. In particular, the inconsistency in classification makes the management and follow-up of patients with preeclampsia challenging. Various studies have measured haemodynamic, vascular physiology and biochemical markers individually , however studies correlating these measurements are few. This project will comprehensively characterise the cardiovascular haemodynamic and endothelial function changes that occur in preeclampsia. From this we will correlate these changs to the various clnical presentations of preeclampsia in an attempt to find a better way to classify and risk stratify this life threatening condition. The ultimate aim is to gain a better understanding of the pathophysiology of preeclampsia and translate this into better management strategies in the future.

Interventions

Observational study of cardiovascular function to be performed in the third trimester of pregnancy and 6 months post-partum period. Pregnant women with preeclampsia, pregant women with pre-existing hypertension and pregnant women without hypertension in preganancy will all be prospectively enrolled to this study. Parameters to be measured include plasma and urine biomarkers of placental and endothelial function, functional measures of small and large vessel reactivity (using aplanation tanometry

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

Pregnant women more then 32 weeks pregnant. They will be divided into three groups: Those diagnosed with preeclampsia as defined by the "international society for the study of hypertension in pregnancy" guidelines, those with pre-existing hypertension and those who are normotoensive on no antihypertensive medication.

Exclusion criteria

1. unable to give informed consent 2. pre-pregnancy cardiovascular disease or diabetes 3. chronic renal disease

Outcome results