None listed
Conditions
Brief summary
This project will determine the acute anti-inflammatory effects of a single bout of exercise in asthma. It is well known that exercise has numerous health benefits; however, research regarding the effect of exercise on airway inflammation in asthma is scarce. This project will examine the mechanisms by which exercise reduces airway eosinophilia in asthma. This research is highly significant to asthma management, as those with asthma have been shown to have very low exercise levels, possibly stemming from the belief that exercise will worsen asthma. We will begin with this study of short-term exercise and use the findings to inform the design of a later study which will examine the effects of exercise training on asthma.
Interventions
Participants will attend four visits.
Visit 1: Two hours prior to visit 1, participants will be directed to consume a carbohydrate-based breakfast (caffeine free). On arrival at the clinic, participants will perform spirometry and plethysmography, have a venous blood sample collected and exhaled nitric oxide (eNO) measured. Participants will then be treated with 400mcg inhaled salbutamol via spacer and spirometry performed 15-minutes post-bronchodilator. Participants will be randomised to compl
Participants will attend four visits. Visit 1: Two hours prior to visit 1, participants will be directed to consume a carbohydrate-based breakfast (caffeine free). On arrival at the clinic, participants will perform spirometry and plethysmography, have a venous blood sample collected and exhaled nitric oxide (eNO) measured. Participants will then be treated with 400mcg inhaled salbutamol via spacer and spirometry performed 15-minutes post-bronchodilator. Participants will be randomised to complete one of the following interventions: 1) 30-minutes of moderate-intensity exercise on a treadmill or 2) 30-minutes of rest. Moderate-intensity exercise will be performed at 60-80% of the age predicted maximum heart rate. At 0, 1 and 2 hours post-exercise/rest a venous blood sample will be collected, eNO measured and spirometry performed. eNO will also be measured and spirometry perfomed 0.5 hours and 4 hours post-exercise. Participants will be instructed to maintain a food diary for the entire day and breakfast the following morning. Visit 2: Visit 2 will be conducted 24 hours after visit 1. Two hours prior to visit 2, participants will be directed to consume the same breakfast they had prior to visit 1. On arrival at the clinic, participants will perform spirometry, have a venous blood sample collected, exhaled nitric oxide (eNO) measured and have an allergy skin prick test. Participants will also complete 7 days of pedometry between visit 2 and visit 3. Visit 3: Visit 3 will be conducted 4 weeks after visit 2. Two hours prior to this visit, participants will be directed to consume the same breakfast as they had prior to visit 1. On arrival at the clinic, participants will perform spirometry, have a venous blood sample collected and exhaled nitric oxide (eNO) measured. Participants will then be treated with 400mcg inhaled salbutamol via spacer and spirometry performed 15-minutes post-bronchodilator. Participants will be randomised to complete the alternate intervention to visit 1: either 1) 30-minutes of moderate-intensity exercise on a treadmill or 2) 30-minutes of rest. Moderate-intensity exercise will be performed at 60-80% of the age predicted maximum heart rate. At 0, 1 and 2 hours post-exercise/rest a venous blood sample will be collected, eNO measured and spirometry performed. eNO will also be measured and spirometry perfomed 0.5 hours and 4 hours post-exercise. Participants will be directed to have the same foods for the entire day as they had during visit 1. Participants will be instructed to maintain a food diary for the entire day and breakfast the following morning. Visit 4: Visit 4 will be conducted 24 hours after visit 3. Two hours prior to visit 4, participants will be directed to consume the same breakfast they had prior to visit 1. On arrival at the clinic, participants will perform spirometry, have a venous blood sample collected and eNO measured.
Sponsors
Hunter Medical Research Institute
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Doctor diagnosed asthma; stable asthma (no respiratory tract infection, oral corticosteroid use or antibiotic use in the 4 weeks preceding the intervention visits); 18-65 years of age and body mass index (BMI) <=40kg/m2; never or ex-smokers (last cigarette at least 6 months prior); FEV1 >50% predicted. GP clearance for exercise must be provided for females aged >50 years, males aged >40 years, and all participants who respond ‘yes’ to any question in Part A of the “Adult Pre-Exercise Screening Tool”.
Exclusion criteria
Current smoker; cardiac contraindication to exercise; cancer; pregnancy or breastfeeding; currently undertaking exercise training (>=90 minutes per week); any issue that in the opinion of the investigator would impede the participants safety and/or ability to undertake the exercise intervention; participation in an exercise session within 3 days of the scheduled study visit.
Outcome results
None listed