Impact of luteal progesterone therapy on endometrial polyps accidentally discovered during routine infertility evaluation: randomized trial.

women with detected endometrial polyps during routine infertility evaluation are randomized to receive luteal phase support by oral dydrogesterone or placebo to find out the impact on pregnancy rate and post-menstrual polyp persistence and size.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613000990729

Enrollment

100

Registered

2013-09-05

Start date

2012-06-09

Completion date

2014-06-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Asymptomatic women with endometrial polyps accidentally discovered during trans-vaginal sonography done for routine infertility evaluation were either given luteal dydrogesterone for endometrial support or placebo and followed up for occurrence of pregnancy and persistence of polyp after period if no pregnancy occurred.

Interventions

luteal phase support by dydrogesterone oral tablets 30 mg/day for 10 days starting 2 days after sonographically detected ovulation. cases were appointed postmenstrually to reevaluate the endometrium and make sure that they received their treatment correctly.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

20 Years to 35 Years

Healthy volunteers

Inclusion criteria

Presence of endometrial polyp in an asymptomatic regularly menstruating woman ,evaluated for infertility for one year or more, and partner normal semen.

Exclusion criteria

other causes of infertility, irregular or abnormal menstrual periods

Outcome results