Prospective evaluation of pterygium excision and conjunctival autograft with autologous blood, fibrin glue, or vicryl sutures

Comparison of autologous blood versus fibrin glue versus vicryl sutures for conjunctival autografts in pterygium surgery, evaluating pain scores, graft stability, and recurrence in healthy adult patients.

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613000986774

Enrollment

Registered

2013-09-04

Start date

2013-11-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Our aim is to study the efficacy of pterygium excision and conjunctival autograft with autologous blood and compare with the gold standards of sutured autograft and autograft with fibrin glue. Conjunctival autografts with autologous blood have been reported to be effective in the literature. Only a small number of prospective studies with small numbers of patients have studied conjunctival autografts with autologous blood. Comparing this method to that with sutures and with fibrin glue will provide meaningful comparative data on efficacy of method, rates of recurrence, cost and patient comfort. We hypothesize that patients will experience less discomfort and will have similar rates of graft stability and recurrence.

Interventions

Excision with conjunctival autograft involves removal of the pterygium leaving an area of bare sclera, which is closed by the movement of a free conjunctival transplant from another part of the ocular surface. The conjunctival autograft will be attached with autologous blood acting as a bioadhesive. The surgical intervention takes approximately 30 minutes and patients will be followed at 1 day, 1 week, 1 month, 3 months, 6 months, and 1 year.

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

Age of patient should be more than 18 years. Primary nasal pterygium. Patient willing to be enrolled in the study and available for all subsequent follow-ups.

Exclusion criteria

Age of patient less than 18 years Recurrent pterygium (history of previous pterygium excision) Temporal pterygium Pterygium >4mm Double headed primary pterygium (arising from both medial and lateral side of cornea) Any previous ocular surface surgery Patient unwilling to participate in the study and all required follow-ups

Outcome results