None listed
Conditions
Brief summary
Lycopene is a carotenoid, present in tomatoes, which has linked to beneficial effects on human health, such as prevention of prostate cancer. Lycopene found in human blood, plasma and tissues contain high levels of cis isomers of lycopene, whereas the trans isomer is the main dietary source of lycopene. Interestingly, processing of tomatoes converts trans isomers to cis isomers and the latter being regarded as more bioavailable, since they are more soluble and better absorbed in the gut. Although it should be noted that isomerisation may also take place in vivo. Processing of food can lead to loss of beneficial nutrients and therefore being able to consume fresh unprocessed tomatoes rich in cis isomer lycopene rather than a processed tomato product may provide additional nutritional benefits.
Interventions
Intervention is, consumption of one dose of tomato, containing 5-20 mg of novel tetra-cis lycopene or containing 5-20 mg standard trans-lycopene. A blood sample will be obtained at 0, 4, 5 and 6 hours and a urine sample will be obtained at 0 and 24 h. There will be a 2 week wash out peroid before consumption of one dose of the altenative variety of tomato. Samples are collected as with the first dose.
Sponsors
The New Zealand Institute of Plant and Food Research
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy adults Pre-screened for normal blood lipid profiles (fasting cholesterol less than 5.2 nmol/L and fasting Plasma-triacylglycerol (TAG) rich lipoprotein Less than 2.3 nmol/L)
Exclusion criteria
Smokers, Frequent alcohol consumption Pregnant women, Regular prescribed medication affecting lipid metabolism, Regular use of carotenoid containing supplements, BMI under18.5 or over 35, Long term illness requiring active treatment (cancer, gastrointestinal disease, cardiovascular disease, diabetes) Regular use of antacids and laxatives (more than once a week), Not willing to discontinue foods containing tomato, guava, watermelon, grapefruit, dried parsley or basil, persimmons, liver pate, asparagus, red cabbage, chillies, papaya or carotenoid containing supplements, laxatives and antacids 1 week prior to and during the trial period. Have donated blood within 16 wk of first sample, Has taken antibiotics within 4 weeks before study start date. Fasting cholesterol greater than 5.2 mmol/L and fasting Plasma-triacylglycerol (TAG) rich lipoprotein greater than 2.3 mmol/L.
Outcome results
None listed