Assessing blood levels of ketorolac ( Toradol) injected in around the hip and knee joints in patients undergoing joint replacements

Pharmacokinetic study of intraarticular and periarticular injection of ketorolac in patients undergoing total hip and knee replacements

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613000923763

Enrollment

Registered

2013-08-21

Start date

2013-10-24

Completion date

2014-12-11

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Participating patients will be screened as per the study protocol and will have prior informed consent. Ten patients with normal renal function undergoing total knee or hip replacement surgeries are chosen for the study. As per the usual procedure in the hospital, surgeon infiltrates the joint with 100ml of 0.2% ropivacaine with adrenaline along with 30mg ketorolac at the end of surgery. Serial blood samples are taken at 30 mins, 1,2,4,8 and 24 hours post infiltration. Serum concentrations of ketorolac will be analysed using HPLC at Biochemical lab, University of Queensland. The results will be analysed by the research team.

Interventions

Studying the blood levels of ketorolac at 30 minutes, 1,2,4,8,24 hours after intraarticular infiltration during total hip and total knee replacements

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

Should be able to speak and understand English Should be able to give an informed consent Patients > 18 yrs of age Both Male and female patients undergoing Total Hip and Total Knee Replacements All patients should have normal renal function Participating patients should have no systemic diseases which include severe heart/lung conditions/bleeding disorders Not on any medications which could alter renal function Patients will not receive any further NSAID’s in the first 24 hrs of surgery

Exclusion criteria

Patients < 18 yrs of age Consent not obtained Impaired renal function Patients with severe cardiovascular / lung diseases Pregnancy/lactation

Outcome results