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Mobile 'App' to Improve Iron and Zinc Intake, Iron and Zinc Status, Cognition, Mood and Fatigue in Premenopausal Women

Improving iron and zinc intake in premenopausal women through either dietary intake or supplements using mobile phone applications and measuring changes in cognition, mood and fatigue compared with control group

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12613000912785
Acronym
WIZE study: Women's Iron, Zinc and Energy study
Enrollment
95
Registered
2013-08-15
Start date
2013-08-26
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Premenopausal women are at increased risk of iron deficiency due to iron losses in menstrual blood and increased requirements during pregnancy. Additionally, inadequate consumption of dietary iron or over-consumption of compounds that impede absorption of iron (e.g. phytate) can result in iron requirements not being met. In addition, women who have a low dietary intake of iron and a low iron level are frequently at risk of a low intake of zinc. Rich dietary sources of iron also tend to be rich sources of zinc. Currently very little is known about the zinc status of Australian women. The aim of this study is to investigate the use of technology to improve iron status, by determining if the dietary advice delivered by the mobile apps can 1) increases intake of bioavailable iron and zinc compared to a control "healthy diet" group; and 2) results in a significant improvement in iron and zinc status and markers of cognition, mood and fatigue compared with a control "healthy diet" group. We hypothesise that: The use of a mobile phone app to optimise intakes of bioavailable iron and zinc over a 16-week period in premenopausal women with low serum ferritin will result in: a) higher dietary intake of bioavailable iron and zinc; b) a greater improvement in iron status; c) a greater improvement in cognition, mood (including indicators of depression and anxiety), fatigue and sleep compared to a control "healthy diet" group.

Interventions

Participants will take part in a 16-week three-arm randomised controlled trial (RCT). Apart from a healthy eating control group, there are two arms involving intervention, including the dietary group and the supplement group. All the participants in the RCT will have different mobile phone app(s) installed in their phones, according to which group they are randomly allocated to. Participants in the intervention group will receive a mobile phone app with an online component that contains fact sh

Participants will take part in a 16-week three-arm randomised controlled trial (RCT). Apart from a healthy eating control group, there are two arms involving intervention, including the dietary group and the supplement group. All the participants in the RCT will have different mobile phone app(s) installed in their phones, according to which group they are randomly allocated to. Participants in the intervention group will receive a mobile phone app with an online component that contains fact sheets and quizzes about dietary iron and zinc, and encourages dietary habits that may maximise iron and zinc absorption through a goal system. The goal system encourages participants to 1) eat two iron-fortified products each day, 2) eat 50 mg of vitamin C with meals, 3) use a point system where foods are assigned points depending on iron content, consume at least 12 points per day, and 4) drink coffee/tea away from meals. Participants in the supplement group will be provided a supplement of 65.7 mg elemental iron daily for the duration for the 16 weeks of the study. The supplement will be taken orally as a film coated tablet. The participants will receive regular reminders of iron supplement intake and dietary advice for a "healthy diet" through mobile phone apps. There will be two apps involved for the supplement group. One app has an online component and contains fact sheets, reminder and a goal system encouraging participants to: 1) limit intake of saturated fat, 2) choose wholegrain foods, 3) reduce sodium intake, and 4) aim to eat 2 serves of fruit and 5 serves of vegetables daily. The second app is the publically available FoodSwitch app developed by Bupa and the George Institute which participants are encouraged to use when shopping for food.

Sponsors

Meat & Livestock Australia Ltd.
Lead SponsorCommercial sector/Industry

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
16 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

Premenopausal women with serum ferritin less than 20 micrograms/L and haemoglobin equal to or greater than 120 g/L

Exclusion criteria

Post-menopausal Currently pregnant or breastfeeding or have been in the past 12 months Currently a blood donor or have donated blood in the past 12 months Does not own a smartphone (iPhone or Android) Haemoglobin less than 120 g/L Serum ferritin equal to or greater than 20 micrograms/L

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026