A clinical trial of adoptive T-cell immunotherapy for patients with Epstein-Barr virus-associated nasopharyngeal carcinoma.

EBV-specific T cell adoptive immunotherapy. Patients will be identified prior to completing three cycles of chemotherapy for metastatic or loco-regionally recurrent NPC. Blood for T cell therapy manufacture must be collected prior to the completion of the third cycle of chemotherapy. This is to allow sufficient time to generate the T cell therapy, to ensure that all patients commence T cell infusions within a similar timeframe after the completion of chemotherapy. If a patient has already commenced chemotherapy, a venesection will occur at the discretion of the Clinical Investigator, based on the fitness of the participant for the venesection, and the patient’s full blood count . Initially, all patients will receive standard chemotherapy (investigator’s choice) for up to 6 cycles, according to standard clinical practice. Following completion of chemotherapy, the tumour will be imaged according to standard procedures, and the level of tumour control will be determined. Patients who experience disease stabilisation, a partial clinical response or a complete clinical response following chemotherapy will be eligible for T cell infusions. Participants who do not experience tumour control will be withdrawn from the study and will receive further standard therapies prescribed by the treating clinicians .. A dose of 2x10^7/m^2 LMP/EBNA1-specific autologous T cells will be given by intravenous infusion at weeks 2,4,6,8,10 and 12