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Comparison of normobaric hypoxia and hypoxic hypoxia protocol on human performance and physiology

In young male population, is there difference in physiology, performance and hypoxia symptoms between normobaric hypoxia and hypobaric hypoxia?

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12613000850774
Enrollment
21
Registered
2013-08-01
Start date
2012-08-03
Completion date
2012-10-25
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

When unexpected situations such as oxygen system failure or loss of cabin pressure occur, a pilot may suffer hypoxia. Without early recognition of hypoxia symptoms and prompt corrective measures, in-flight hypoxia could affect cognition and judgment, even jeopardize flight safety. Hypoxia symptoms are determined by inherent tolerance, among other factors.It is believed that “hypoxia signature”, aconstellation of hypoxia symptoms, is unique for each individual. To familiarize with hypoxia symptoms, all military pilots in Taiwan have to undergo hypoxia awareness training by exposing themselves to simulated hypoxia environment in altitude chamber. This hypobaric hypoxia (HH) training protocol has the potential danger of decompression sickness and barotrauma. Alternatively, normobaric hypoxia (NH) training has been developed involving breath low concentration of oxygen at sea level. NH is safer, more economical andtime saving. However, there’s no conclusion as to whether NH protocol can faithfully imitate altitude hypoxia, as represented by HH protocol currently implemented in many countries as the mainstay of hypoxia awareness training. The purpose of this study is to compare the physiological responses, performances and hypoxia symptoms between HH and NH hypoxia awareness training protocol.

Interventions

normobaric hypoxia: subjects in sitting position, exposed to hypoxia by inhaling 7% oxygen through face mask at sea level hypoxia duration < 5 min (depend on invidual tolerance and SpO2) Each participant undergo the two sessions on one occasion only. Each sessions are separated by at least 48 hours.

Sponsors

National Defense Medical Center
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Educational / counselling / training
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
Male
Age
20 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

healthy volunteer able to detect middle cerebral artery blood flow by doppler at temporal region.

Exclusion criteria

1. pulmonary disease (asthma, COPD, pneumothorax, pulmonary tuberculosis) 2. claustrophobia 3. heart disease 4. severe anemia

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026