None listed
Conditions
Brief summary
Magnesium is used successfully to treat asthma exacerbations. Although COPD and asthma share common pathophysiology and first line therapies in acute exacerbations, little is known about the role of magnesium in acute exacerbations of COPD. We aim to investigate whether magnesium used in conjunction with standard treatments provides better bronchodilation when compared with placebo with standard treatments.
Interventions
Intravenous magnesium sulphate 2 mmols diluted in 15mls of saline, administerered over 15minutes via infusion pump. This will be done only once. Patients will be followed up upto 2 hours post administration. Length of stay and outcome data will be collected after 1 month.
Sponsors
Saptarshi Mukerji
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
35 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Known previous diagnosis of COPD, presented to ED with a primary diagnosis of acute exacerbation of COPD.
Exclusion criteria
Anyone deemed to require immediate NIV or mechanical ventilation on presentation. Patients who are unable to carry out spirometry. Other active problems that may be life threatening. Hypotension. Pregnancy.
Outcome results
None listed