Comparison of effect of honey with cough syrups containing dextromethorphan and codeine on cough associated with upper respiratory tract infection in adults: a randomized trial

In patients with cough associated with upper respiratory tract infection , is honey better than cough syrups containing dextromethorphan and codeine in improving cough.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613000817741

Enrollment

Registered

2013-07-24

Start date

2009-08-03

Completion date

2010-02-03

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary reason reason for conducting this trail is to highlight the role of honey as a possible relieving agent in cough associated with upper respiratory tract infection (URIs). Since we all know that most of the URIs are in self limiting but its symptoms are troublesome. Mostly over the counter non prescription cough syrups are used which contain codeine and its derivative leading to sedation and other side effects. honey has shown benefit in children with cough, so we wanted to explore this effect on adults.Thus we conducted a randomized trial to compare the effect of honey and cough syrups for the improvement of cough associated with URI in adult population at CHC clinics Aga Khan University Hospital (AKUH) Karachi.

Interventions

There were two treatment groups in the study. One group received honey 30 ml per day in three divided doses for 3 days (10 ml three times a day)per oral with the measured spoon given with the intervention Pure bee honey (langnese) was used. To ensure patient adherence to medicines, a reminder phone call at day 2 of treatment was given to the patients by study coordinator. a card was also given to patient to record their daily doses.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

We included all patients 18-65 years of age presenting within 7 days history of cough due to URI visiting Community health center, Aga khan university hospital, not requiring antibiotics.

Exclusion criteria

Patients with signs or symptoms of pneumonia, asthma or COPD exacerbation, already taking honey or any cough syrups, using drugs known to inhibit the metabolism of dextromethorphan and pseudoephridine (such as selective serotonin reuptake inhibitor), history of Diabetes Mellitus, using ACE inhibitors,current smoker, not providing consent and pregnant women were excluded

Outcome results