None listed
Conditions
Brief summary
The incidence of type 1 diabetes has increased worldwide, particularly in younger children and those with lower genetic susceptibility. These observations are consistent with environmental effects that promote pancreatic islet autoimmunity and destruction of insulin-producing beta cells. The Environmental Determinants of Islet Autoimmunity (ENDIA) Study is investigating candidate environmental exposures and gene-environment interactions that may contribute to the development of islet autoimmunity and type 1 diabetes.
Interventions
This is a pregnancy/birth cohort study of children with a first-degree relative with type 1 diabetes. Pregnant mothers and their infants will be followed prospectively from early pregnancy through childhood to investigate relationships between the development of islet autoimmunity (and subsequently type 1 diabetes) and prenatal and postnatal environmental factors. Investigation will involve 3-monthly assessments of the mother during pregnancy, then 3-monthly assessments of the child until 24 mon
This is a pregnancy/birth cohort study of children with a first-degree relative with type 1 diabetes. Pregnant mothers and their infants will be followed prospectively from early pregnancy through childhood to investigate relationships between the development of islet autoimmunity (and subsequently type 1 diabetes) and prenatal and postnatal environmental factors. Investigation will involve 3-monthly assessments of the mother during pregnancy, then 3-monthly assessments of the child until 24 months of age and 6-monthly thereafter. The initial duration of the study is until the child reaches three years of age. We would like to continue to follow these children longer-term into adolescence to determine the relationship between genotype and early environment and the development of islet autoimmunity and type 1 diabetes. Participants will be asked to sign a separate consent form to follow their children from three to ten years of age.
Sponsors
University of Adelaide
Eligibility
Sex/Gender
All
Age
0 to 6 Months
Healthy volunteers
Yes
Inclusion criteria
An unborn child with a first-degree relative with type 1 diabetes, targeting the mother for recruitment during pregnancy from six weeks gestation onwards, or an infant less than six months of age with a first-degree relative with type 1 diabetes. A first-degree relative may be the child's mother, father or sibling.
Exclusion criteria
Incapacity for the pregnant woman, or in the case of postnatal recruitment the child’s primary caregiver, to understand the requirements of her and/or her child’s participation in the study.
Outcome results
None listed