Relationship between peak temperature and survival of neutropenic sepsis in intensive care

In patients in intensive care units with neutropenic sepsis, is there an association between peak temperature within the first 24 hours and in-hospital mortality?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613000784718

Enrollment

10000

Registered

2013-07-15

Start date

2013-07-29

Completion date

2014-08-29

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In patients in intensive care with severe infections, those who do not develop a fever during the first 24 hours are more likely to die. This study aims to find out whether this is also the case in patients with infections in the absence of functioning white blood cells ('neutropenic sepsis'). We will look at a database of patients who were in intensive care in Australia and New Zealand between 2000 and 2013, to see whether there is a link between peak fever during the first 24 hours and survival among patients with very low white blood cell counts, compared with those with normal white blood cell counts. This study will inform the development of future clinical trials to decide whether the common medical practice of reducing fever during severe infections is harmful or not.

Interventions

This is an observational study. The condition observed is peak temperature, as recorded in the ANZICS-APD database, within the first 24 hours in the intensive care unit.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

All patients admitted to an adult ICU at one of 157 centres in Australia and New Zealand between 2005 and 2013 for whom information is available on the Australian and New Zealand Intensive Care Society (ANZICS) Adult Patient Database (APD). "Neutropenic sepsis" cohort: White cell count equal to or less than 1.0 x10^9/L within the first 24 hours on the intensive care unit APACHE-II diagnostic code indicating infection or haematological malignancy "Neutropenic sepsis with haematological malignancy" cohort: White cell count equal to or less than 1.0 x10^9/L within the first 24 hours on the intensive care unit APACHE-II diagnostic or comorbidity code indicating haematological malignancy "Non-neutropenic sepsis" cohort: White cell count greater than or equal to 4.0 x10^9/L during the first 24 hours on the intensive care unit APACHE-II diagnostic code indicating infection

Exclusion criteria

No recorded white cell count during first 24 hours on intensive care unit No recorded temperature during first 24 hours on intensive care unit For "Non-neutropenic sepsis" cohort only: APACHE-II diagnostic code or comorbidity code indicating a haematological malignancy

Outcome results