Effect of sodium and potassium supplementation on blood vessel function

Effect of sodium and potassium supplementation on blood vessel function in healthy adults

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613000772741

Enrollment

Registered

2013-07-10

Start date

2013-07-09

Completion date

2014-05-16

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study is determine the effect of sodium to potassium ratio on postprandial endothelial function in healthy subjects. We speculate that a low sodium to potassium ratio improves postprandial endothelial function compared to high sodium to potassium ratio.

Interventions

Arm 1) High potassium, high sodium meal (38mmol potassium; 65mmol sodium) Arm 2) Low potassium, high sodium meal (3.1mmol potassium; 65mmol sodium) Each meal is consumed within 5minutes and there is a minimum 7day washout between visits

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

18-70yr BMI greather than 18kg/m2 and less than 30kg/m2 SBP <90mmHg DBP<130mmHg weight stable for 6mo

Exclusion criteria

Use of antihypertensive medication, systemic steroids, folate supplementation or non-steroidal antiinflammatory drugs Metabolic disease such as liver or kidney disease Treated hypertension Previous clinical cardiovascular disease Unable to comprehend protocol

Outcome results