None listed
Conditions
Brief summary
There is a need to better understand the mechanisms involved in peritoneal membrane deterioration in patients undergoing peritoneal dialysis. We have found that a recently discovered particle (calciprotein particle, CPP) is present at high levels in drained out peritoneal dialysis fluid (PDF). Experimental work suggests that CPP may promote inflammation and calcification in certain situations. This is a pilot study to ascertain whether differences in PDF composition, in particular with respect to fluid glucose and calcium concentration, effect the formation and levels of CPP present in drained PDF. We hypothesise that PDF containing higher glucose and calcium concentrations would be associated with greater intra-peritoneal CPP accumulation, which may predispose to peritoneal inflammation, calcification and ultimately, technique failure.
Interventions
Assessing the peritoneal dialysis effluent for the presence of calciprotein particles. Once a week for 8 weeks, in no particular order, participants will administer a specified PD fluid bag (listed below) and return that bag of effluent for analysis. The PD bags are:
1. Dianeal 1.5% PD4
2. Dianeal 4.25% PD4
3. Physioneal 1.36% PD4
4. Physioneal 3.86 % PD4
5. Extraneal 7.5%
6. Nutrineal 1.1%
7. Dianeal 1.5% PD2
8. Dianeal 1.5% PD1
Sponsors
Eastern Health Integrated Renal Service
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Peritoneal dialysis patients A peritoneal equilibration test (PET) within the last 6 months
Exclusion criteria
Unable to comply with the protocol Allergy or problem with one of the PD fluid solutions proposed Peritonitis within the last 6 weeks
Outcome results
None listed