None listed
Conditions
Brief summary
Wholegrains are rich in nutrients and other substances with antioxidant activity that have the potential to benefit human health, in a similar way to the effects of fruits and vegetables. Wholegrain foods have been associated with reduced weight gain, slowly digested carbohydrates and improved heart health, particularly in studies of populations that consume certain wholegrains as a staple food. We wish to investigate if some positive effects can be identified and measured in people consuming specific wholegrains in a single meal. This study aims to demonstrate the immediate effects of eating a range of wholegrain breakfasts on appetite and blood levels of glucose, appetite hormones and antioxidants. Therefore, this study is a very important step towards building evidence for specific wholegrains as important foods in appetite control and disease prevention.
Interventions
Intervention: Participants will undergo 3 test meals and 1 control meal. The order they receive the meals will be randomised.
Test meals: 45grams of flaked wholegrain cereal biscuits derived from 3 different varieties of sorghum grain. The different test biscuits that are expected to have variable rates of starch digestibility and polyphenol content.
Control meal: 45g wholegrain breakfast meal using comparator cereals.
Duration of administration: Breakfast meals and subsequent 4 hours, fol
Intervention: Participants will undergo 3 test meals and 1 control meal. The order they receive the meals will be randomised. Test meals: 45grams of flaked wholegrain cereal biscuits derived from 3 different varieties of sorghum grain. The different test biscuits that are expected to have variable rates of starch digestibility and polyphenol content. Control meal: 45g wholegrain breakfast meal using comparator cereals. Duration of administration: Breakfast meals and subsequent 4 hours, following 12 hours overnight fast with a prior standardised dinner the night before. Time of administration: Morning breakfast meal. Frequency of administrations: 4 test days separated by a minimum 3-7 day washout period. Females will be tested during the same phase of their menstrual cycle.
Sponsors
Sanitarium
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
18-50 year old men and women Willing to attend research facility on 4 occasions for a period of 5 hours plus an initial pre-study interview for 1.5hours. BMI 18.5-33
Exclusion criteria
Unwilling to consume a breakfast meal comprising of wholegrain cereal with water on four occasions Existing allergies/intolerances to wheat or gluten Smokes cigarettes Know or suspect pregnancy or are breastfeeding Diabetes Major illnesses BMI <18.5 and >33 Have been taking antioxidant supplements, Vit C within 2 weeks of study (if randomised into bloods group) Irregular menstrual period Iron deficiency Cannot understand English
Outcome results
None listed