None listed
Conditions
Brief summary
The use of the laryngeal mask airway in children has increased with increasing day-case surgery in paediatric patients. Successful insertion of the laryngeal mask requires adequate mouth opening and sufficient depth of anaesthesia to minimise the upper airway reflexes and to prevent the untoward events of coughing, gagging and laryngospasm. Although propofol is a commonly used induction agent due to its depressant effects on airway reflexes, propofol alone does not prevent undesirable airway responses.Consequently, a potent and short-acting opioid (for example alfentanil ) is often added to facilitate laryngeal mask insertion in adults with minimal haemodynamic changes.However, the optimal bolus dose of alfentanil for children in this context has not been established. This study was designed, therefore, to determine the optimal dose of alfentanil required for the successful insertion of the laryngeal mask airway with a single bolus dose of propofol at induction (2.5 mg/kg)without a neuromuscular blocking agent in children.
Interventions
A predetermined bolus dose of alfentanil was injected over 30 seconds, followed by propofol 2.5 mg/kg over 10 seconds. The bolus dose of alfentanil was determined by a modified Dixon’s up-and-down method, starting from 10 microg/kg (2microg/kg as a step size). Laryngeal mask insertion was attempted 90 seconds after the end of alfentanil injection and the response of patients was classified as either ‘success’ or ‘failure’.
Sponsors
Yusheng Yao
Eligibility
Sex/Gender
All
Age
3 Years to 7 Years
Healthy volunteers
No
Inclusion criteria
ASA 1 and 2 patients of either gender of the age 3- 7 years undergoing elective surgery under general anaesthesia which can be performed with LMA insertion
Exclusion criteria
airway malformations, clinical evidence of patients with difficult airway, asthma or any sign of upper respiratory tract infection.
Outcome results
None listed