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Can a Mediterranean dietary pattern improve vascular function, cognitive health and psychological wellbeing?

Dietary intervention for cognitive and cardiometabolic health in a healthy elderly population

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12613000602729
Acronym
MedLey
Enrollment
166
Registered
2013-05-27
Start date
2013-05-30
Completion date
2014-07-09
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In a 6 month dietary intervention trial, we aim to investigate the effects of an Australianised Mediterranean Diet on cognitive functioning, cardiovascular health and wellbeing in an elderly Australian free-living population. We will assess memory, executive functioning, verbal fluency and speed and accuracy, psychological well-being, weight, changes in body composition, blood lipids, blood pressure, inflammatory markers, blood glucose and insulin, and vascular endothelial function. We expect to find that an Australianised Mediterranean diet will show greater improvements in these outcomes when compared to a habitual diet.

Interventions

An Australianised Mediterranean Diet (MedDiet) based on the traditional Cretan Mediterranean diet, providing 100% of energy requirements for weight maintenance for 6 months in an elderly population (age 65 years or older). The MedDiet will consist of a high intake of vegetables, legumes, fruits, virgin olive oil, non-refined bread and cereal products and nuts; a moderate intake of low fat dairy products and lean poultry; a low intake of red meat, added sugar, salt and saturated fat, and moderat

An Australianised Mediterranean Diet (MedDiet) based on the traditional Cretan Mediterranean diet, providing 100% of energy requirements for weight maintenance for 6 months in an elderly population (age 65 years or older). The MedDiet will consist of a high intake of vegetables, legumes, fruits, virgin olive oil, non-refined bread and cereal products and nuts; a moderate intake of low fat dairy products and lean poultry; a low intake of red meat, added sugar, salt and saturated fat, and moderate intake of red wine (if alcohol is habitually consumed) according to the NHMRC guidelines (2 drinks or less per day). The diet will aim to provide 35-40% energy from fat with >50% coming from monounsaturated fat, 15% energy from lean protein and 40-45% energy from carbohydrate. This should achieve a ratio of monounsaturated to saturated fat of 2. Physical activity will remain unchanged throughout the trial. This is a 6 month study and volunteers will undergo outcome assessments at baseline and again at 3 and 6 months. Each assessment timepoint will be conducted over 2 mornings (approx. 2hrs in duration) separated by a week.

Sponsors

Dr Karen Murphy (Chief investigator)
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
65 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

Male and females aged 65 years or more, proficient in English language, omnivorous, DemTect score 13 or over, free of dementia, non-smoker

Exclusion criteria

Subjects who report one or more of the following: history of head/brain injury, neurological or psychiatric conditions, previous stroke, using medication for neurological or psychiatric conditions, current or recent (past 6 months) malignancy, major liver, kidney, respiratory, gastrointestinal disease, current cardiovascular disease or angina, uncontrolled hypertension (>170/100), actively undertaking a weight loss program, use of appetite suppressants or Orlistat, participation in another dietary intervention study within 30 days of commencement of the present study, smoker, or any person considered by the investigator to be unwilling, unlikely or unable to comprehend or comply with the study protocol.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 17, 2026