None listed
Conditions
Brief summary
This study looks at the treatment of post tonsillectomy pain. The pain experienced is severe and has a tendency to get worse five to seven days after surgery. This often has an impact on the patient’s oral intake prolonging the return to normal activity. The narcotics given for pain control are often associated with side effects. Non-steroidal anti-inflammatory drugs, such as Celecoxib (Celebrex(trademark) are superior for the control of pain minus the side effects. In this study the patient will be randomised to one of two groups and given a study pack on discharge. Both packs contain an antibiotic (Penicillin) and a “rescue” analgesic (Oxycodone - Endone(Trademark) ). One pack contains paracetamol and one contains paracetamol and Celecoxib/Celebrex. Patients will be asked to chart their recovery until their pain ceases. A data collection chart will be given to each patient on discharge. Each patient will be followed up in outpatients 5 days and 4 weeks post-surgery.
Interventions
The administration of a non-steroidal anti-inflammatory drugs, celecoxib,( Celebrex(trademark)) , for the control of post tonsillectomy pain Post operatively, patients will receive regular analgesics routinely given to post tonsillectomy patients. with allowance for IV Morphine as rescue analgesia, Ondansetron / Maxalon Metoclopramide (taken orally) as antiemetic and other medications deemed necessary.. 2 doses of IV Dexamethasone 8mg will be given to all patients post-operatively and on the first morning post surgery. Upon discharge patients will be supplied with a treatment or placebo pack. Both packs contain Paracetamol (1gm (4 times per day) 12 days), Penicillin (500mg (twice per day) 5 days), endone (5mg (as required) /6 hrly) and either Placebo (2 capsules (twice per day) 7 days) OR Celecoxib ((200 mg capsules), 2 capsules (twice per day), 7 days)). All medications are taken orally Study participants will be asked to return all unused medications to the study coordinator at the final outpatient appointment. These will be checked against their patient drug diary to ensure protocol adherence.
Sponsors
Study design
Eligibility
Inclusion criteria
Over 18 years Undergone a tonsillectomy
Exclusion criteria
(1) Other concomitant surgical procedures (2) Allergic to NSAIDS/opioids/codeine/endone/paracetamol/sulphonamide (3) Asthma (4) Kidney disease (5) Liver disease (6) Cardiovascular disease (7) Hemorrhagic disease (8) Hypertension (9) OSA (10) Women trying to conceive, pregnant or nursing (11) Patients taking clebrex