A randomised controlled study investigating neurally adjusted ventilatory assist (NAVA) application during non-invasive ventilation (NIV) in Paediatrics.

The effect of neurally adjusted ventilatory assist (NAVA) application compared to standard non invasive ventilation (NIV) on length of ventilation, length of PICU stay, oxygenation and sedation requirements in paediatrics requiring NIV.

Status

Not yet recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613000598785

Acronym

NIV+NAVA

Enrollment

366

Registered

2013-05-27

Start date

2013-08-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Non-invasive ventilation (NIV) as a mode of respiratory support is growing in poopularity and a number of studies have demonstrated it's benefit in both adults and children. Difficulties associated with NIV are largely attributed to leakage around the mask which adversely affects triggering and results in a time lag between patient effort and the ventilator's response. Neurally adjusted ventilatory assist (NAVA) uses an oesophageal probe which detects diaphragmatic innervation for every breath. This results in a much more timely co-ordination of ventilatory support.

Interventions

Non-invasive ventilation via a mask using the neural triggering available in the mode of NAVA. Neurally Adjusted Ventilatory Assist (NAVA) is a recent highly innovative triggering design. NAVA uses an oesophageal probe which detects diaphragmatic electric activity. Diaphragmatic electric activity is the first physiological response in initiating a breath. By relying on diaphragmatic innervation the ventilator provides a timely response to patient effort that is not affected by air leaks around t

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

0 to 18 Years

Healthy volunteers

Inclusion criteria

Requiring respiratory support using NIV

Exclusion criteria

1. Facial and/or head injuries that prohibit application of the mask and strapping 2. Inability to maintain airway 3. Lack of intrinsic respiratory drive

Outcome results