None listed
Conditions
Brief summary
Lifestyle factors such as exercise and diet remains the cornerstone in the management of type 2 diabetes. Progressive resistance training is one mode of exercise that can improve glycaemic control and other metabolic risk factors that contribute to the development of diabetes complications. Whether diet and exercise combined can have added benefits remains unknown. In non-diabetic adults, high protein diets can enhance the benefits of resistance training on muscle mass and strength. There is also evidence that vitamin D deficiency is associated with glucose intolerance and insulin resistance, which can be improved with treatment. This study builds upon our current community-based resistance training program, titled ‘Lift for Life (L4L)’, to examine whether post-exercise ingestion of a protein enriched drink and vitamin D can enhance the benefits of resistance training on glycaemic control, body composition and cardiometabolic health in adults with type 2 diabetes. This study is important as the findings will underpin more precise exercise and nutrition guidelines for the management of glycaemic control and cardiometabolic risk factors in people with type 2 diabetes, along with the ongoing refinement of community-based initiatives for the management of this condition.
Interventions
A 6-month, randomised controlled trial in which participants with type 2 diabetes will participate in a progressive resistance training program (termed Lift for Life) and receive a daily protein enriched drink and vitamin D supplements for 6 months. The Lift for Life program is an individually tailored and supervised group-based community-based program in which participants undertake progressive resistance training twice a week for the first 8 weeks and then three times each week thereafter. Eac
A 6-month, randomised controlled trial in which participants with type 2 diabetes will participate in a progressive resistance training program (termed Lift for Life) and receive a daily protein enriched drink and vitamin D supplements for 6 months. The Lift for Life program is an individually tailored and supervised group-based community-based program in which participants undertake progressive resistance training twice a week for the first 8 weeks and then three times each week thereafter. Each session will last 45-60 minutes and target all major muscle groups. Participants will perform 3 sets of 8-10 repetitions at a weight that cannot be lifted for more than 8-10 repetitions. Training will be made progressively more challenging by incorporating the principle of progressive overload (increments of 2-10% weekly). All training is supervised by accredited Lift for Life exercise trainers. To increase protein intake and vitamin D status, participants will be asked to consume a protein enriched drink each day that will contain approximately 20 g of protein and take two 1000 IU vitamin D3 capsules daily for the duration of the study. On the training days, participants will also be asked to consume a second protein enriched drink after training. Exercise logs and completed exercise cards regularly checked by the trainers will be used to monitor exercise adherence. Adherence to the drinks will be monitored using a daily calendar and counting any remaining drinks at 3 and 6 months. Compliance to the supplements will be monitored by a capsule count from bottles returned at 3 and 6 months.
Sponsors
Deakin University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Males and females aged 50 to 75 years with established type 2 diabetes, treated with diet alone or oral hypoglycaemic agents (not insulin). All participants enrolled in the study must also have received approval from their local physician to participate in the community-based Lift for Life resistance training program.
Exclusion criteria
Participants will be excluded based on the following: 1) glycemic control (HbA1c) >10%; 2) current or prior participation in progressive resistance training (>1 week) or moderate-intensity physical activity >=150 min/week for >3 months; 3) vitamin D and/or calcium supplement use (>500 IU/d and >600 mg/d) in the past 3 months; 4) severe orthopaedic, cardiovascular or respiratory conditions that would preclude participation in an exercise program, or those with absolute contraindications to exercise according to American College of Sports Medicine (ACSM) guidelines; 5) renal impairment (eGFR <45 mL/min/1.73m2) or disease; 6) use of protein supplements; 7) conditions that may affect vitamin D or calcium metabolism; 8) current smoker, or 9) BMI >40 kg/m2.
Outcome results
None listed