None listed
Conditions
Brief summary
We will conduct a 2-year randomised controlled trial to investigate the efficacy and safety of progressive resistance strength training of the foot and ankle in 60 children with Charcot-Marie-Tooth disease (CMT). We will test the hypothesis that progressive resistance strength training is a safe intervention that will improve strength, disability, gait and quality of life in children affected by CMT.
Interventions
Intervention group: High-dose progressive resistance strength training
Type of intervention: Extending and flexing the foot with progressive loading of weight using an ankle cuff.
Frequency: 3 x 25 min sessions per week plus 30 minutes rest after each session
Mode: One supervised training session at hospital and five home-based training sessions with parental supervision per fortnight
Dose: 2-3 sets of 8 repetitions at 50-70% of 1RM for 24 weeks. 1RM is measured every fortnight to adjust the wei
Intervention group: High-dose progressive resistance strength training Type of intervention: Extending and flexing the foot with progressive loading of weight using an ankle cuff. Frequency: 3 x 25 min sessions per week plus 30 minutes rest after each session Mode: One supervised training session at hospital and five home-based training sessions with parental supervision per fortnight Dose: 2-3 sets of 8 repetitions at 50-70% of 1RM for 24 weeks. 1RM is measured every fortnight to adjust the weight lifted. Adherence is monitored by an exercise diary documenting the number of training sessions completed and the intensity experienced with the Borg scale.
Sponsors
Joshua Burns, PhD
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
6 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
Children aged 6-17 years with a confirmed diagnosis of Charcot-Marie-Tooth disease (CMT)
Exclusion criteria
Strength training 3-months prior to recruitment; acute foot or lower limb injuries (e.g. fracture, ankle sprain); previous intra-articular foot surgery (e.g. fusion); an inability to actively dorsiflex (<10% of norm); non-ambulant; inability to comply with the research protocol (e.g. prolonged absence); hypertension; cardiovascular conditions which are exacerbated by exercise; diagnosis of inflammatory arthritis, diabetes or other peripheral neurological disorder; highly dependent on medical care; people with a cognitive impairment, an intellectual disability or a mental illness or insufficient knowledge of the English language to complete the required questionnaires during the study.
Outcome results
None listed