None listed
Conditions
Brief summary
An ileal pouch is formed when the end of the small bowel is used to create a pouch and anastomosed to the anus. This is required in patients who need removal of all their colon and rectum, most commonly for ulcerative colitis. The ileal pouch mucosa (or lining) exists in a state of a varying degree of chronic inflammation. When this is more severe clinical pouchitis develops. Pouchitis is most likely due to an alteration in the microbiota that the ileal mucosa is exposed to. The microbiota alter due to increased stasis of the contents of the ileal pouch, compared to ileum in the normal state. From our previous research and that of others, certain bacteria are associated with less inflammation and certain with more inflammation. We have selected a bacterial culture from previous research that is associated with a healthy pouch. We have been able to develop this bacterium into a probiotic. We wish to use this probiotic as a dietary supplement to see if we can improve the health, function and quality of life in ileal pouch patients.
Interventions
A freeze dried probiotic powder taken in one gelatin capsule taken twice a day for 8 weeks. Each capsule will contain 10^9 colony-forming units of (bacterium name) per capsule.
To monitor compliance at the end of 8 weeks all participants will be asked to return the dispensing container with any unused capsules.
Sponsors
University of Otago
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Functioning ileal J pouch for ulcerative colitis
Exclusion criteria
unable to provide informed consent
Outcome results
None listed