None listed
Conditions
Brief summary
The purpose of this project is to test whether vitamin D supplementation over the winter improves mood. Epidemiological evidence has linked low vitamin D status to a range of mood disorders, including major depressive disorder, seasonal affective disorder, and premenstrual syndrome. New Zealanders are low in vitamin D during the winter season; however, studies examining whether vitamin D supplementation can improve mood-related outcomes are limited.
Interventions
Vitamin D oral capsule in six monthly doses of 50,000 IU.
A blood sample will be taken at the beginning and end of study to confirm effectiveness of the dose in increasing serum 25(OH)D. To achieve adherence, participants take the first dose under supervision, and receive text reminders to take all other 5 doses with a request to confirm having taken the dose with a return text. At the end of the study, participants will be asked to return their supplement bottles with any remaining capsules.
Pa
Vitamin D oral capsule in six monthly doses of 50,000 IU. A blood sample will be taken at the beginning and end of study to confirm effectiveness of the dose in increasing serum 25(OH)D. To achieve adherence, participants take the first dose under supervision, and receive text reminders to take all other 5 doses with a request to confirm having taken the dose with a return text. At the end of the study, participants will be asked to return their supplement bottles with any remaining capsules. Participants will complete monthly online surveys on depression, wellbeing and moods.
Sponsors
Dr Lisa Houghton
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
*Females aged 18-40 years *Cell phone/internet access *Willingness to provide repeated blood sample
Exclusion criteria
*Current/planned vitamin D supplementation (including as part of combined supplement) *Chronic liver and kidney disease; arteriosclerosis or cardiac function impairment; sarcoidosis and other possible granulomatous diseases *Medication, including anticonvulsants, glucocorticoids and barbiturates that might affect vitamin D metabolism *Overseas travel during study period (Feb-Oct 2013)
Outcome results
None listed