Effects of carbohydrates of differing molecular-size on diarrhoea-predominant irritable bowel syndrome (IBS-D)

Effects of carbohydrates of differing molecular-size on faecal water content, gastrointestinal symptoms and breath hydrogen in patients with IBS-D

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613000501741

Enrollment

Registered

2013-05-07

Start date

2013-05-06

Completion date

2013-07-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The low FODMAP diet is effective in managing symptoms in many patients with irritable bowel syndrome. To assess if liberalisation of the diet is possible while still maintaining good symptom control, it is hypothesised that longer-chain FODMAP sugars (inulin) is less fermentable and less osmotic in the large intestine and will therefore not contribute to symptoms as much as shorter-chain FODMAPs (fructo-oligosaccharides and lactulose). Glucose is not a FODMAP, but a sugar that is well absorbed and it is hypothesised that glucose will not contribute to symptoms. Diarrhoea-predominant patients with reported good symptom control on a low FODMAP diet will be recruited for easier measuring of symptom change, bowel motions and faecal water content specifically.

Interventions

Participants will ingest the following single dose solutions fasted (on waking) in a random order with a minimum of three day washout period before crossing over to all of the other solutions: Arm 1 - 20g Lactulose in 100mL solution Arm 2 - 20g Fructo-oligosaccharide in 100mL solution Arm 3 - 20g Inulin in 100mL solution Arm 4 - 20g Glucose in 100mL solution

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients with diarrhoea-predominant irritable bowel syndrome with reported good symptom control while following a low FODMAP diet

Exclusion criteria

1. Organic disease or condition predisposing the patient to diarrhoea (e.g. coeliac disease, inflammatory bowel disease, bowel resection) 2. Use of antidiarrhoeal medications for one week prior to study commencement 3. Probiotic or prebiotic use for two weeks prior to study commencement 4. Antibiotic use for two weeks prior to study commencement

Outcome results