Dexmeditomedine for mitral valve replacement

dexmeditomedine for heart rate control during mitral valve replacement for mitral stenosis a randomised controlled double blind study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613000495729

Enrollment

Registered

2013-05-03

Start date

2011-11-05

Completion date

2013-05-02

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

testing the efficacy and safety of dexmeditomedine in controlling heart rate in patients with tight mitral stenosis subjected to mitral valve replacement during the prebypass period

Interventions

70 patients scheduled for mitral valve replacement divided equally into two groups were studied in this randomized controlled double blind study ; Group D : received (after induction of anesthesia) dexmeditomedine 1ug/kg bolus dose over 10 minutes followed by an infusion of 0.5 ug/kg/h till the start of cardiopulmonary bypass. Group F: received saline bolus ( after induction of anesthesia ) and infusion of saline till the start of cardiopulmonary bypass instead of dexmeditomedine .Anesthetic man

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

patients ASAI&II with tight ( less than one centimeter ) mitral stenosis aged 18-60 years of age scheduled for mitral valve replacement

Exclusion criteria

age above or below 18-60 years , mitral valve area more than one centimeter, renal or hepatic dysfunction , cardiac medications that affect heart rate

Outcome results