The Effect of Intranasal Dexmedetomidine Premedication on the Minimum Alveolar Concentration of Sevoflurane for the Insertion of Laryngeal Mask Airway in children

The Effect of Intranasal Dexmedetomidine Premedication on Reducing the Minimum Alveolar Concentration of Sevoflurane for the Insertion of Laryngeal Mask Airway in Children

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613000462785

Enrollment

Registered

2013-04-23

Start date

2013-05-13

Completion date

2013-11-28

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Sevoflurane is widely employed for inhalational induction of general anaesthesia in children. There is increasing evidence that dexmedetomidine is an effective and safe sedative in children. Laryngeal mask airway is an useful device for pediatric anesthesia. The aim of the current study was to determine whether Intranasal dexmedetomidine premedication can reduce MAC of sevoflurane for an LMA insertion in children

Interventions

GroupD1 received 1mcg/Kg intranasal dexmedetomidine premedication 45min before general anaesthesia; GroupD2 received 2mcg/Kg intranasal dexmedetomidine premedication 45min before general anaesthesia;the intervention and the participants will be monitored throughout the duration of the procedure with follow up ending 4 hours after the procedure has been completed

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

3 Years to 7 Years

Healthy volunteers

Inclusion criteria

ASA 1 and 2 patients of either gender of the age 3- 7 years undergoing elective strabismus surgery under general anaesthesia which can be performed with LMA insertion

Exclusion criteria

Exclusion criteria: airway malformations, clinical evidence of patients with difficult airway, asthma or any sign of upper respiratory tract infection.

Outcome results