None listed
Conditions
Brief summary
The primary purpose of this pilot study aims to determine the effectiveness of treating this particular viral eye infection (adenoviral conjunctivitis) with a one-time in-office irrigation of the eye with 5% povidone-iodine. We aim to determine whether this treatment reduced the period of infection as well as improving patient’s symptoms'.
Interventions
Patients will be given 2 tablets of 200mg ibuprofen in office prior to treatment. 2 drops of 0.4% preservative-free oxybuprocaine will be placed in the lower lid of both eyes prior to treatment. This is followed by 5 drops of 5% povidone-iodine in both eyes. 0.9% sterile sodium chloride wil be used to completely irrigate both eyes for 60 seconds after povidone-iodine application.
Preservative-free Blink Intensive tears (active ingredient: polyethylene glycol 0.25%) will be given and the partic
Patients will be given 2 tablets of 200mg ibuprofen in office prior to treatment. 2 drops of 0.4% preservative-free oxybuprocaine will be placed in the lower lid of both eyes prior to treatment. This is followed by 5 drops of 5% povidone-iodine in both eyes. 0.9% sterile sodium chloride wil be used to completely irrigate both eyes for 60 seconds after povidone-iodine application. Preservative-free Blink Intensive tears (active ingredient: polyethylene glycol 0.25%) will be given and the participant will be instructed to place 1 drop in both eyes every 2 hours until the first review the next day, and as required thereafter. Participants will be asked on the frequency of using the drops at follow-up examinations.
Sponsors
Ben Ashby
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
14 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients must have a positive result on the RPS Adeno Detector, plus at least one of the clinical signs of conjunctival redness, follicles or lymph adenopathy; and at least one of the symptoms of irritation, watering or photophobia.
Exclusion criteria
Patient with a history of allergy to anaesthetic eye drops or a known sensitivity to iodine. Patient who are susceptible to having an adverse reaction to NSAIDs, have a contraindication or are on medications that may interact adversely with ibuprofen. This includes the following: - An history of allergy to NSAID - Asthmatic patient - Gastrointestinal disorders (or history of), including dyspepsia, Crohn’s disease, colitis, gastrointestinal haemorrhage, perforation or ulcer, melaena - Heart/cardiac impairment (or history of), including cardiac failure, myocardial infarction (heart attack), angina pectoris, stroke - Liver disorders (or history of), including hepatitis, jaundice and abnormal hepatic function - Kidney/renal impairment (or history of), including haemutria, interstitial nephritis, renal failure, nephrotic syndrome, proteinuria, renal papillary necrosis - Pregnant or breastfeeding women - Hypertension including those on hypertension medication - Currently taking the following medications: aspirin, diuretics, lithium, hypertensive drugs including ACE inhibitors, beta blockers and diuretics, steroids, zidovudine, probenecid, antidiabetic medication, phenytoin, methotrexate, anticoagulants, SSRIs.
Outcome results
None listed