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Can knee muscle activation be altered using modified clinical exercises in patients with osteoarthritis?

Does the activation of muscles crossing the knee change when comparing standard and modified clinical exercises in individuals with knee joint osteoarthritis?

Status
Not yet recruiting
Phases
Phase 2
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12613000448741
Enrollment
30
Registered
2013-04-19
Start date
2013-04-29
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The National Health and Medical Research council’s Guideline for non-surgical management of Hip and Knee Osteoarthritis includes recommendations for the use of quadriceps strengthening specifically, and resistance training more generally. However, further research is needed to best identify what exercise prescription has maximal benefit. Individuals with late stage osteoarthritis have been shown the preferentially activate the muscles more laterally when compared with healthy individuals. The aim of this study is to identify which clinical exercises cause a more balanced activation between the medial and lateral muscles of the lower limb. The results of this study may help give better understanding into roles of specific muscles in knee osteoarthritis patients, in ways to better distribution load, thereby, assisting practitioners in prescribing efficient exercises in treating symptoms and preventing knee osteoarthritis. It is expected that modified clinical exercises will result in a more balanced, or more medial activation of the muscles crossing the knee

Interventions

Participants will need to complete a series of clinical exercises. Participants will be given specific instruction on how to perform each of the following exercises; heel raise, wall squat, straight leg raise and step up. This will allow participants time to become familiar with the exercise. Participants will perform a total of 4 exercises with 2 variations being assessed (Normal exercise/ Modified exercise). 1 set of 10 repetitions will be performed with 2minutes rest between each exercise.

Participants will need to complete a series of clinical exercises. Participants will be given specific instruction on how to perform each of the following exercises; heel raise, wall squat, straight leg raise and step up. This will allow participants time to become familiar with the exercise. Participants will perform a total of 4 exercises with 2 variations being assessed (Normal exercise/ Modified exercise). 1 set of 10 repetitions will be performed with 2minutes rest between each exercise. The participants will perform the activity with little instruction during the normal exercise, then repeat the exercise with specific modifications to you if this changes muscle activation. All exercises will only be performed on one occasion. Performing the calf raise (CR) will require the participant to stand with both feet on edge of step, with the heels hanging off the edge (1). Keeping the body erect, rise onto the forefeet (2). Then slowly drop heels below level of the step and repeat (3). The modified calf raise (MCR); the participant will be asked to stand with both feet hip width apart on the edge of the step, with the heels hanging off the edge (1). Keeping the body in an erect position, rise up through the “big toe” (2). Then slowly drop heels below level of the step and repeat (3). Performing the straight leg raise (SLR); the participant will be positioned in a supine position, where they will be asked to bend knee of the non-affected side to flatten for back support (1). Lock knee of the affect leg out straight and lift leg to a height parallel to the bent knee (2). Then lower leg until it touches the bed, and then lift again, ensuring that the knee remains straight (3). The modified exercise “45deg straight leg raise; the participant will be asked to lay a supine position with a bent knee of the non-affected side to flatten and support lumbar spine (1). Lock the knee of the affected leg out straight, and externally rotate the thigh by turning the “toes outwards 45deg” (2). Lift the leg a height just below the opposite bent knee (3). Then lower leg until it touches the bed, and then lift again, ensuring that the knee remains straight (4). Performing the Wall squat (WS); the participant will be positioned with their back against the wall (1). Placing the heels about thigh width from the wall and hip width apart (2). Ensuring that knee do not extend over toes slowly lower the trunk until the knees are bent through a 60deg range, progressing further as tolerated (3). The modified wall squat (MWS) will include a ball squeeze with pressure cuff to maintain equal squeeze pressure. Participants will be asked positioned with their back against the wall (1), Place the heel about thigh width from the wall and hip width apart (2). Place a ball with sphygmomanometer between the knees and measure the level of squeeze (3). Ensuring that knee do not extend over toes, slowly lower the trunk until the knees are bent through a 60deg range, progressing further as tolerated (4). Performing the step up the participant will be asked to initially stand facing a step (step height=10-15cm)(1). Proceed to step up straight ahead with the affected leg, ensuring that the knee always remains on a line between the hip and foot until the unaffected foot is on the step (2). Emphasis should be placed on maintaining balance, correct upright posture, abdominal bracing, good knee alignment and pelvic/gluteal control (3). Slowly lower back down on the unaffected leg maintaining correct balance, knee alignment with abdominal and pelvic control and repeat (4). The modified variation step up will involve an altered foot position marked out a specific angle. The participant will be required to proceed to step up straight onto the taped angle with the affected leg, ensuring that the knee always remains on a line between the hip and foot until the unaffected foot is on the step (2). Emphasis should be placed on maintaining balance, correct upright posture, abdominal bracing, good knee alignment and pelvic/gluteal control (3). Slowly Lower back down on the unaffected leg while maintaining correct balance, knee alignment with abdominal and pelvic control and repeat (4).

Sponsors

Murdoch University
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
50 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

Patient Group: Medial compartment tibiofemoral compartment osteoarthritis scored as Kellgren and Lawrence Grade 3 or 4 Control Group Asymptomatic

Exclusion criteria

Patient Group: Any neurological condition Rheumatic disease other than osteoarthritis Significant involvement of the lateral tibiofemoral compartment (Kellgren and Lawrence Grade 2 or higher) Any other current lower limb injuries Control Group Any neurological condition Rheumatic disease other than osteoarthritis Osteoarthritis in the lower limb Any other current lower limb injuries

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026