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Do cost-effectiveness analyses underestimate the benefits of preventing disability in preterm infants? A systematic review

Systematic review of randomised trials and observational studies in preterm infants of interventions to prevent long-term disability

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12613000394741
Acronym
CEAPOD-PTI Cost effectiveness analyses of prevention of disability in preterm infants
Enrollment
25
Registered
2013-04-10
Start date
2012-02-01
Completion date
2012-12-31
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

More than one in ten infants are born preterm, with increased risk of disability. To guide public policy reliably, cost-effectiveness analyses of interventions to prevent disability require a long-term societal perspective, including costs of hospital treatment, special education, family or community care, and lost parent and child productivity. Methods: We evaluated (i) the proportion of cost effectiveness analyses with a long-term societal perspective and (ii) whether analyses with a long-term societal perspective were more frequent within randomised controlled trials (RCTs). Original, peer-reviewed research articles in English from 1 January 2002 through 31 December, 2012 were eligible for inclusion in the review if they described cost-effectiveness analyses of interventions before or after preterm birth and reported disability. Searches by two reviewers in The Cochrane Library, EconLit, EMBASE and MEDLINE databases yielded 220 articles. Reference lists from those articles yielded another 5 articles. Of these 225 articles 25 described cost-effectiveness analyses that met the inclusion criteria.

Interventions

Any antenatal, intrapartum or postnatal intervention in pregnancy before 37 weeks gestation or in infants of less than 37 weeks gestation with disability as an outcome.

Sponsors

WINNER Centre for Newborn Research, NHMRC CTC University of Sydney
Lead SponsorUniversity

Eligibility

Sex/Gender
All
Age
0 to 1 Months
Healthy volunteers
No

Inclusion criteria

Any type of clinical study including RCTs, observational studies or a search of the published literature, which included both the costs and consequences of an intervention and its comparator. Studies must include interventions in pregnant women or newborn babies before 28 days after birth. Studies are eligible if published between 1 January 2002 and 31 December 2012

Exclusion criteria

Stillbirths

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026