Is Dexmedetomidine protective from postoperative cognitive dysfunction in elderly patients after prolonged surgical anesthesia?

Status

Not yet recruiting

Phases

Phase 1

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613000378729

Enrollment

Registered

2013-04-09

Start date

2013-05-10

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

30 patients, above 60 years old of both sex who will be scheduled for elective abdominal surgery under general anesthesiafor more than two hours will be selected to participate in this study, Patients will be randomized into 2 groups (15 patients in each group) Group (D) Dexmeditomedine : will receive sevoflurane inhalation,fentanyl, Rocronium and Dexmeditomedine infusion (0.4 mic/kg/hour) Group (s) Sevoflorane (or the control group) will receive sevoflurane inhalation,fentanyl, Rocronium and Saline infusion . For both groups, Neurocognetive tests (Montreal Cognetive Assessment and Stroop color word interference tests) will be done the night before the surgery and will be repeated 24 hours postoperatively

Interventions

Group (D) Dexmeditomedine : will receive sevoflurane inhalation,fentanyl 100 mic, Rocronium 50 mg.and Dexmeditomedine infusion (0.4 mic/kg/hour)continous infusion from the start of the surgery till skin closure. Group (s) Sevoflorane (or the control group) will receive sevoflurane inhalation,fentany100 mic.l, Rocronium 50 mg and Saline infusion . For both groups, Neurocognetive tests (Montreal Cognetive Assessment and Stroop color word interference tests) will be done the night before the su

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

60 years old or above, bothe sexes without any neuropsychatric disorder, Scheduled for prolonged (two hours or more) abdominal surgery

Exclusion criteria

Patients with any psychological or neurological disorder,or with preexisting cognitive dysfunction. patients with cardiac disease

Outcome results