None listed
Conditions
Brief summary
Aim of the study is to diagnose and compare the incidence of postoperative cognitive dysfunction after two commonly used types of general anesthesia – inhalational and intravenous - in the healthy middle age population. Combination of standardized psychometric tests and electophysiological examination will be used for detection of cognitive disorder at different time intervals after the operation.
Interventions
Total intravenous anesthesia - maintained by propofol infusion according to Roberts dosing scheme, adjusted by Bispectral index. Sufentanil (approx. 0,3 mcg/kg) will be used as analgetic component and rocuronium (0,6 mg/kg) for muscle relaxation. Mixture of air and oxygen for ventilation. Approx. duration of anesthesia 60 min.
Sponsors
Dpt. of Anesthesia and Intensive Care of the Faculty of Medicine Plzen - Charles University Prague
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
40 Years to 49 Years
Healthy volunteers
No
Inclusion criteria
patients undergoing elective resection of intervertebral disc herniation given and signed informed consent Czech as the native language finished high school
Exclusion criteria
Abnormal results of preoperative neuropsychological and electrophysiological tests Disease of central nervous system Addiction (also in history) Psychiatric disease, use of psychiatric medication Sleep apnoea syndrome Perception disorder Allergy or intolerance of drugs used for anesthesia
Outcome results
None listed