None listed
Conditions
Brief summary
In both human and animal studies combined amino acid plus exercise interventions have improved outcomes associated with cardiovascular health (Yoshizawa 2010) and metabolic flexibility above either therapy alone (D'Antona 2010, Sasai 2011, Kim 2011). The purpose of this study is to determine the effect of combined amino acid and exercise therapies on cardiovascular health, glycaemic control and mechanisms important to insulin sensitivity in the skeletal muscle of non-insulin dependent type-2 diabetics.
Interventions
Participants randomised to the AA + EX group will underake a 10-week weekday morning small-group mixed-mode exercise program and consume a pre- and post-exercise supplement. All sessions willl be supervised by exercise physiologists. The exercise program entails 3 days of 20 minutes of interval cycling on an ergometer for 20 minutes at 30% and 60% of maximal work capacity, and 2 days of 30 minutes of upper-body resistance circuit training at 60% of 1 repitition maximum plus core exercises (plus
Participants randomised to the AA + EX group will underake a 10-week weekday morning small-group mixed-mode exercise program and consume a pre- and post-exercise supplement. All sessions willl be supervised by exercise physiologists. The exercise program entails 3 days of 20 minutes of interval cycling on an ergometer for 20 minutes at 30% and 60% of maximal work capacity, and 2 days of 30 minutes of upper-body resistance circuit training at 60% of 1 repitition maximum plus core exercises (plus warm up and cool down exercises). Maximal cycling work capacity and maximum strength on resistance exercises will be reassesed fortnightly and workloads adjusted to maintain prescribed intensities. The treatment is a 200ml pre-packaged drink containing 15g whey protein, 3g leucine, 15g carbohydrate, and 5g of fat. Drinks will be consumed immediately before and after exercise and at the same time by participants in the supplement only group.
Sponsors
Massey University Wellington
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
Male
Age
40 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
Non-insulin dependent Type-2 diabetics (T2DM)diagnosed for a minimum of 1 year, HbA1c between 7 and 9%, BMI 25-32, stable weight and non-participation in regular exercise in past 6 months.
Exclusion criteria
Use of beta-blockers, moderate to severe retinopathy, nephropathy and neuropathy, history of cerebrovascular or cardiovascular diseases, or evidence of other clinical contraindications preventing moderate to high-intensity exercise, including cardiac irregularities that may appear during baseline maximal aerobic testing.
Outcome results
None listed