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Sun Exposure and Vitamin D Supplementation for mild vitamin D insufficiency in Australian Adults

Comparison of sun exposure advice and vitamin D supplementation for the management of mild vitamin D deficiency in Australian adults

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12613000290796
Acronym
SEDS Study
Enrollment
532
Registered
2013-03-14
Start date
2013-09-03
Completion date
2016-08-31
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Vitamin D deficiency is common in Australia. But Australia has high skin cancer incidence. While advice is given on safe sun exposure to avoid the risks of skin cancer, it is not clear how much sun exposure is required, at different locations in Australia, to maintain sufficient vitamin D levels throughout the year. This study thus addresses the following public health questions: 1). Can safe patterns and doses of sunlight exposure achieve and maintain vitamin D adequacy with no vitamin D supplementation? and 2). How does sun exposure advice calibrate against 2 different doses of vitamin D3 supplementation to manage mild vitamin D deficiency? We will recruit 228 Australian adults aged 18-64 years who have been diagnosed with mild vitamin D deficiency on routine testing (25(OH)D of 40-60nmol/L) in each of four regions in Australia - Canberra, Melbourne, Brisbane, Perth. Participants will be randomly allocated to one of four groups receiving different types of sun exposure advice and supplementation. Outcomes will be the proportion of participants who are vitamin D sufficient at 12 months, and at the end of winter, the time when vitamin D levels are usually lowest.

Interventions

Two groups will receive vitamin D supplementation: oral cholecalciferol 600IU/day and cholecalciferol 2000IU/day. These groups will receive standard (Cancer Council) sun exposure advice Enhanced sun exposure advice - advice to receive as much sun exposure as possible to as much exposed body surface as is practicable, without experiencing sunburn, on as many occasions as possible. A control group will receive placebo capsules and standard sun exposure advice. All participants will receive the

Two groups will receive vitamin D supplementation: oral cholecalciferol 600IU/day and cholecalciferol 2000IU/day. These groups will receive standard (Cancer Council) sun exposure advice Enhanced sun exposure advice - advice to receive as much sun exposure as possible to as much exposed body surface as is practicable, without experiencing sunburn, on as many occasions as possible. A control group will receive placebo capsules and standard sun exposure advice. All participants will receive the intervention over a 12 month period.

Sponsors

National Centre for Epidemiology and Population Health
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years
Healthy volunteers
Yes

Inclusion criteria

aged 18-64 years serum 25-hydroxyvitamin D concentration of 40-60nmol/L on routine testing Fitzpatrick Skin type 2-4

Exclusion criteria

Current supplementation with vitamin D, cod liver oil, calcium Relevant medical conditions: hypercalcemia, sarcoidosis, kidney stones, photosensitivity diseases, hepatic or renal failure History of melanoma, squamous cell carcinoma or more than five basal cell carcinoma in the last 5 years Receiving phototherapy Immobility Pregnant or lactating

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 18, 2026